爱丽丝(艾伦·波斯蒂恩 Ellen Burstyn 饰)是一名全职太太,多年在家相夫教子,过着平静幸福的生活,然而,某日,她的丈夫在一场意外中去世了,带着十一岁的儿子汤米(阿尔弗雷德·卢特三世 Alfred Lutter III 饰),这对母子不得不步入冷酷的社会,开始为两人的未来打拼。
年轻的时候,爱丽丝热爱唱歌,如今,她带着汤米来到了一座小城定居,在酒吧卖唱。某日,爱丽丝遇见了名为本(哈威·凯特尔 Harvey Keitel 饰)的男人,强壮自信的本唤醒了爱丽丝内心压抑已久的感情,就在她以为幸福的生活将要来临之时,却发现自己不过是坠入了另一个噩梦之中,面对接连而来的挫折,爱丽丝还能够坚强的生活下去吗?
American psychologist John Holden arrives in London to participate in a symposium aiming to expose witchcraft and devil-worship as a fraud, with attention centered on a cult run by a Julian Karswell. Debarking his plane, Holden learns that the symposium leader, Henry Harrington, has suddenly died and he is now in charge. What only the audience knows is that Harrington was clearly killed by a demon, apparently summoned by Karswell to avenge his persecution. Despite both threatening and cajoling behavior by Karswell, Holden determines to proceed, though the only cult member willing to talk about his experiences is in a prison psychiatric ward, catatonic after allegedly killing yet another cult member. However, Harrington's niece, Joanna, believes, based on her uncle's notes, that Karswell may indeed have some satanic powers derived from an ancient tome in an obscure language which he has been able to translate, and attempts to warn the skeptic Holden. Karswell's mother also attempts to warn Holden off. However, the thing which begins to most get to Holden are the occasional, but mounting, sensory and mental disturbances he begins experiencing after an encounter with Karswell, and the discovery that, during this encounter, Karswell secretly slipped a slip of parchment with a curse in runic symbols on it into Holden's belongings, a parchment identical to one Harrington recorded having had passed to him in a similar manner shortly before his death... [N.B. Holden at no point stays at the Karswell estate].
弗兰克(尼古拉斯·凯奇 Nicolas Cage 饰)是一名急救医生,这个争分夺秒的工作让他在日积月累间承担了许多无形的压力。弗兰克救过很多人的性命,但也眼睁睁的看着很多人无奈的死去。这一次,他的急救对象是一个名叫罗斯(Cynthia Roman 饰)的女孩,不幸的是,罗斯最终死去。罗斯的死给弗兰克带来的前所未有的巨大打击,他甚至出现了幻觉,精神濒临崩溃。
在另一次抢救任务中,弗兰克遇见了老人波克(Cullen O. Johnson 饰)和他的孙女玛丽(帕特丽夏·阿奎特 Patricia Arquette 饰),波克的重病让他生不如死,在玛丽和波克的默许下,弗兰克主动结束了老人的生命。而对于弗兰克来说,波克的死带来的是解脱和救赎。